Plenhyage XL Medium is an injectable polynucleotide formulation developed for professional aesthetic use in skin quality treatment protocols. It contains 2% high molecular weight polynucleotides derived from highly purified salmon sperm DNA and is supplied as a 2ml sterile glass syringe. Positioned as a non-volumising injectable, Plenhyage XL Medium is selected by practitioners seeking to support skin elasticity, hydration balance, and overall dermal quality without altering facial contours. It is commonly incorporated into treatment plans addressing visible signs of ageing, photoageing, reduced skin elasticity, and areas of textural irregularity. The formulation is biocompatible and resorbable. Within aesthetic practice, it is frequently used on the face, neck, and décolleté, where skin may present with laxity, dehydration, or environmental stress. It may also be considered in areas presenting with fibrotic tissue changes, depending on practitioner assessment. Plenhyage XL Medium is classified as a Class III Medical Device (CE 0373) and is intended strictly for administration by trained medical professionals. It is suitable for use as a standalone protocol or as part of combination treatment planning where skin quality optimisation is the primary objective. How It Works Plenhyage XL Medium delivers high molecular weight polynucleotides into the dermal layer through controlled microinjection techniques. Polynucleotides are used within aesthetic medicine to support the extracellular environment and hydration dynamics of the skin. When placed intradermally, the formulation integrates into the dermal matrix and is gradually resorbed. It is associated with supporting fibroblast activity and maintaining tissue elasticity, contributing to improved dermal quality over a structured treatment course. Key Benefits • Supports skin elasticity and dermal resilience • Contributes to improved hydration balance • Suitable for photoaged and environmentally stressed skin • Non-volumising injectable formulation • Biocompatible and resorbable polynucleotide solution
