Nucleofill Medium is a polynucleotide-based skin booster developed for general facial revitalisation and broader skin quality improvement. It forms part of the updated Nucleofill portfolio, which has transitioned from the original structure of Nucleofill 20, Nucleofill 25 and Nucleofill Eyes into a clearer, indication-led system. Nucleofill Medium directly replaces the former Nucleofill 20. It maintains a comparable polynucleotide concentration and clinical positioning, offering a balanced formulation suited to early and moderate skin ageing concerns. Within aesthetic practice, Nucleofill Medium is commonly selected for: Reduced skin elasticity Early laxity Fine lines Dull or environmentally stressed skin Preventative regenerative protocols Unlike structural dermal fillers, this product is positioned as a regenerative skin quality treatment. It is suitable for use across multiple anatomical areas, including the face, neck, hands and abdomen, where gradual tissue support is clinically appropriate. In the revised Nucleofill range: Soft Plus replaces Nucleofill Eyes for delicate tissue Medium replaces Nucleofill 20 The previous Nucleofill 25 category has now been divided into Medium Plus and Strong Plus to separate moderate and advanced indications This clearer segmentation supports more precise treatment planning and product selection. How It Works Nucleofill Medium contains polymerised polynucleotides formulated in a gel suitable for intradermal use. Polynucleotides have hydrophilic properties that support tissue hydration. They also contribute to a favourable extracellular matrix environment, supporting fibroblast activity and normal collagen and elastin production processes. The product is designed to: Support dermal hydration Contribute to improved skin elasticity Assist with overall skin quality improvement Its action is regenerative and supportive rather than volumising. Key Benefits Medium-density PN formulation for general facial use Suitable for multiple anatomical areas Supports improvement in skin texture and elasticity Non-volumising approach to skin quality Can be incorporated into preventative treatment plans
